"Resistance" is a song by English alternative rock band Muse, featured on their fifth studio album The Resistance. Written by vocalist, guitarist and pianist Matthew Bellamy, it was released as the third single from the album, following "Uprising" and "Undisclosed Desires", on 22 February 2010.

Muse are an English rock band from Teignmouth, Devon, formed in 1994. The band consists of school friends Matthew Bellamy (lead vocals, lead guitar, piano, keyboards, keytar), Christopher Wolstenholme (bass, vocals, keyboards, Misa Kitara, harmonica) and Dominic Howard (drums, percussion, synthesisers).

Muse are known for their energetic and extravagant live performances and their fusion of many music genres, including space rock, progressive rock, alternative rock, symphonic rock and electronica. They were also nominated for five Grammy Awards, of which they won Best Rock Album, for their fifth studio album The Resistance (2009). To date, Muse have sold over 15 million albums worldwide.

Most earlier Muse songs lyrically dealt with introspective themes, including relationships, social alienation, and difficulties they had encountered while trying to establish themselves in their hometown. However, with the band's progress, their song concepts have become more ambitious, addressing issues such as the fear of the evolution of technology in their Origin of Symmetry (2001) album. They deal mainly with the apocalypse in Absolution (2003) and with catastrophic war in Black Holes and Revelations (2006). The Resistance (2009) was a concept album based around the plot and themes of Nineteen Eighty-Four by George Orwell. Their latest album, The 2nd Law (2012) relates to economics, thermodynamics, and apocalyptic themes.